Editorial (Thematic Issue: Novel Statistical Approaches for High-dimensional Gene-gene and Gene-environment Interaction Analyses)
نویسندگان
چکیده
منابع مشابه
Novel Statistical Approaches for High-dimensional Gene-gene and Gene-environment Interaction Analyses
With the advance of high-throughput technologies, large-scale genetic studies have been popularly used to uncover novel genes predisposing to complex traits. During the past decade, numerous genes have been identified through genome-wide association, exome-sequencing, and whole-genomesequencing studies, some with compelling biological plausibility for a role in complex traits. Despite such succ...
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In this brief primer, we hope to provide a general overview on statistical methods for disease-gene mapping. Of course, this cannot be complete—our apologies to researchers whose methods are not mentioned below. More-detailed information may be found in relevant textbooks (Ott 1999) and at the Web Resources of Genetic Linkage Analysis site (Laboratory of Statistical Genetics, Rockefeller Univer...
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Atrial fibrillation (AF) is a heritable disease that affects more than thirty million individuals worldwide. Extensive efforts have been devoted to the study of genetic determinants of AF. The objective of our study is to examine the effect of gene-gene interaction on AF susceptibility. We performed a large-scale association analysis of gene-gene interactions with AF in 8,173 AF cases, and 65,2...
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The literature on candidate gene associations is full of reports that have not stood up to rigorous replication. This is the case both for straightforward main effects and for candidate gene-by-environment interactions (Duncan and Keller 2011). As a result, the psychiatric and behavior genetics literature has become confusing and it now seems likely that many of the published findings of the la...
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The effects of genetic variants on phenotypic traits often depend on environmental and physiological conditions, but such gene-environment interactions are poorly understood. Recently developed approaches that treat transcript abundances of thousands of genes as quantitative traits offer the opportunity to broadly characterize the architecture of gene-environment interactions. We examined the g...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2016
ISSN: 1389-2029
DOI: 10.2174/138920291705160803183450